New Publication by Anja Riesel and Kai Härpfer!

24 November 2025, by Anke Ellegast

We are pleased to announce the publication of our latest article by Kai Härpfer and Anja Riesel, which introduces an integrative model of altered error-related brain activity and psychopathology. In this publication, the authors review the current literature on the role of an altered error-related negativity (ERN) as a transdiagnostic risk factor across internalizing, externalizing, and thought disorders. They highlight early shaping factors that influence the development of hypo- or hyperactive neural error monitoring systems, as well as potential catalysts that translate neural risk into clinical symptoms. The resulting integrative model offers a comprehensive framework for future clinical research and the development of personalized interventions, grounded in a neurobiological understanding of psychopathology.

Härpfer, K., & Riesel, A. (2026). On the role of neural error monitoring in clinical research: An integrative model of altered error-related brain activity and psychopathology. Clinical Psychology Review, 123, 102673. https://doi.org/10.1016/j.cpr.2025.102673